Virtual Data Rooms (VDRs) are safe and reliable methods to access confidential documents in business transactions. VDRs are a great tool for performing due diligence in mergers and acquisitions. They also help companies organize important documents and share them with investors and other stakeholders. VDRs are also used to store and organize contracts, invoices and other documents, for legal reasons such as litigation or estate planning.
Members should examine their current procedures and the equipment used on their vessels that have VDR/SVDR installed. It is also advisable to to look at upgrading and replacing those that are outdated or that don’t meet minimum safety requirements.
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the expression of proteins that are involved in a variety of physiological processes.
The VDR is present in neurons, as well as a subset glial cells, which form part of the brain. In the primary hippocampal culture of rat, immunoreactivity for the VDR was detected in the oligodendrocytes. The VDR also appears to be present in human neuroblastoma and astrocytes. The treatment of HL-60 leukemia cell lines by 1,25(OH2)2D3 resulted in monocyte-like differentiation and increased VDR levels. This effect was blocked by inhibitors of PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.
